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Sodium Carbonate → 4-(3',4'-Dichloro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | Methyl 4-(4-bromophenyl)-4-oxobutanoate | HCID 838865 | — |
| 反応物 | 3,4-Dichlorobenzeneboronic acid | HCID 2734330 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-(3',4'-Dichloro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester | HCID 86583519 | — |
反応手順
In a manner similar to Example 12, Step (b), (3,4-dichloro-phenyl)boronic acid (1.0569 g, 0.005539 mol) was allowed to react with 4-(4-bromo-phenyl)-4-oxo-butyric acid, methyl ester (1.3636 g, 0.005019 mol) in the presence of tetrakis(triphenylphosphine(palladium(0) (0.1054 g, 0.0000912 mol) and 2.0 M aqueous sodium carbonate (5.5 mL, 0.011 mol) in toluene (11 mL) to give, after chromatography on silica gel (270 g, 230-400 mesh), eluting with hexanes-acetone (7:1) 1.432 g of 4-(3′,4′-dichloro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester as a white solid: mp 120-121° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06307089B2 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-1af08d6387ee4d3b9a858f098df12c36 |
| 出典メモ | uspto-grants-2001_10 |