関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Pyrrole-2-carboxaldehyde | HCID 13854 | — |
| 反応物 | 4-bromo-2,3-dihydro-1H-indol-2-one | HCID 2763190 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 溶媒 | Piperidine | HCID 8082 | — |
| 生成物 | HCID 59971430 | HCID 59971430 | — |
反応手順
A mixture of 4-bromo-1,3-dihydro-2H-indol-2-one (0.2 g, 0.94 mmol) (see Kosuge et al., supra), and excess pyrrole-2-carboxaldehyde (0.11 g, 1.13 mmol) (Aldrich) in 1% piperidine in 2-propanol (2 mL) was heated at 85° C. for 2 h. Hot water (2 mL) was added. On cooling, the crystallized product was filtered off, washed with aqueous 2-propanol and dried. (Yield 0.26 g, 96%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06307056B1 |
|---|
| 出典データセット | uspto-grants-2001_10 |
|---|
| ORD ID | ord-fb8c200ef8b14006b47ac1d51ac9f564 |
|---|
| 出典メモ | uspto-grants-2001_10 |
|---|
