2,5-Dihydro-2,5-dimethoxy-3-phenylfuran → 2,5-Dimethoxy-3-phenyltetrahydrofuran
反応式
[CH3:1][O:2][CH:3]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][CH:5]([O:14][CH3:15])[O:4]1>CCOC(C)=O.[Rh]>[CH3:1][O:2][CH:3]1[CH:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:6][CH:5]([O:14][CH3:15])[O:4]1参加物
4
実験手順
A mixture of 2,5-dihydro-2,5-dimethoxy-3-phenylfuran (590 mg, 2.86 mmol) and 10% Rh/Al2O3 (110 mg) in EtOAc (10 mL) was stirred under H2 atmosphere for 24 hours. The catalyst was filtered onto Celite and rinsed with EtOAc. The filtrate was concentrated in vacuo to afford 583 mg (98%) of 2,5-dimethoxy-3-phenyl-tetrahydrofuran as a colorless oil which was typically used without further purification.
後処理
- filtrationThe catalyst was filtered onto Celite
- washrinsed with EtOAc
- concentrationThe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-8792c64d56494174b278534e84dcc627
- 出典データセット
- uspto-grants-2001_10
- 特許番号
- US06306892B1
反応ノート
読み込み中…