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L-2-aminohexano-6-lactam → 3(RS)-(3-Biphenyl-4-yl-1H-imidazol-1-yl)-N-(hexahydroazepin-2-on-3(S)-yl]succinamic Acid Benzyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-2-aminohexano-6-lactam | HCID 440599 | — |
| 反応物 | 2(RS)-(3-biphenyl4-yl-1H-imidazol-1-yl)-succinic acid 4-benzyl ester | HCID 54141298 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3(RS)-(3-Biphenyl-4-yl-1H-imidazol-1-yl)-N-(hexahydroazepin-2-on-3(S)-yl]succinamic Acid Benzyl Ester | HCID 53846884 | 67.2% |
反応手順
According to the procedure described in Example 8(a), 2(RS)-(3-biphenyl4-yl-1H-imidazol-1-yl)-succinic acid 4-benzyl ester (1.20 g, 2.82 mmol) and L-α-amino-ε-caprolactam (469 mg, 3.67 mmol) was coupled in DMF with pyBOP to furnish 1.02 g (67%) of 3(RS)-(3-biphenyl-4-yl-1H-imidazol-1-yl)-N-(hexahydroazepin-2-on-3(S)-yl)succinamic acid benzyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06306892B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-db7c1073da88466c8b77b1abf9da3885 |
| 出典メモ | uspto-grants-2001_10 |