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Dimethylformamide dimethyl acetal → (E)-ethyl 2-((dimethylamino)methylene)-3-oxopentanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 反応物 | Ethyl 3-oxovalerate | HCID 78656 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (E)-ethyl 2-((dimethylamino)methylene)-3-oxopentanoate | HCID 11820077 | 100% |
反応手順
According to Scheme 9 Step 1: A solution of ethyl 3-oxopentanoate (13.9 mmol, 2.00 g) and of 1,1-dimethoxy-N,N-dimethylmethanamine (13.9 mmole, 1.84 mL) in DMF (10 mL) was microwaved for 30 min at 120° C. After evaporation of the solvent, 2.76 g (13.9 mmol) of (E)-ethyl 2-((dimethylamino)methylene)-3-oxopentanoate were obtained and used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524718B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-36ed30f54e374bdc94cf8a2fd6430b5a |
| 出典メモ | uspto-grants-2013_09 |