Benzaldehyde → 4-Benzylideneamino-5-imidazolecarboxamide

HRID 382361ノート

反応式

HRID 382361 の反応式
Cl.[NH2:2][C:3]1[N:4]=[CH:5][NH:6][C:7]=1[C:8]([NH2:10])=[O:9].C(N(CC)CC)C.[CH:18](=O)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.O>C(O)C>[CH:18](=[N:2][C:3]1[N:4]=[CH:5][NH:6][C:7]=1[C:8]([NH2:10])=[O:9])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

6

反応物 4

HCID 240BenzaldehydeHCID 962WaterHCID 8471TriethylamineHCID 661465-Aminoimidazole-4-carboxamide hydrochloride

生成物 1

HCID 539704464-Benzylideneamino-5-imidazolecarboxamide収率 97.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
0 °C

実験手順

16.3 g (100 mmol) of 4-amino-5-imidazolecarboxamide hydrochloride was suspended in 200 ml ethanol, and 27.8 ml (200 mmol) of triethylamine was added to the suspension and dissolved. To the solution, 10.2 ml (100 mmol) of benzaldehyde was added and the mixture was heated for 8 hours while refluxing. After the addition of 400 ml of distilled water, the reaction mixture was stirred for one hour at 0° C. A solid precipitate produced was collected by filtration, washed with distilled water, then with ethanol, and dried under reduced pressure to obtain 20.8 g of the title compound (yield 97%).

後処理

  1. dissolutiondissolved
  2. temperaturethe mixture was heated for 8 hours
  3. temperaturewhile refluxing
  4. customA solid precipitate produced
  5. filtrationwas collected by filtration
  6. washwashed with distilled water
  7. dry with materialwith ethanol, and dried under reduced pressure

出典と根拠

ORDレコード
ord-de6431ae773b4bcd9b792e1bd6fcfc05
出典データセット
uspto-grants-2001_10
特許番号
US06310070B1

反応ノート

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