Methylamine → 4-[(Ethylamino)sulfonyl]benzoic acid

反応式

Cl[S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH2:14]([NH2:16])[CH3:15].CN>>[CH2:14]([NH:16][S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3])[CH3:15]

参加物

反応物 3

HCID 6329Methylamine

HCID 6341Ethylamine

HCID 823854-(Chlorosulfonyl)benzoic acid

生成物 1

HCID 6117664-[(Ethylamino)sulfonyl]benzoic acid収率 64%

実験手順

A reaction was carried out following the conditions of Example 32 using 4.4 g (20 mmol) of 4-chlorosulfonylbenzoic acid and an ethylamine solution instead of the 40% aqueous solution of methylamine. The reaction product was post-treated to obtain 2.92 g of 4-ethylaminosulfonylbenzoic acid (yield 64%).

後処理

additionThe reaction product was post-treated

出典と根拠

ORDレコード: ord-1d7bc9aff01a4cf78574cc20dc121891
出典データセット: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06310070B1

反応ノート

読み込み中…