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3-Pyridineacetic acid, hydrochloride (1:1) → 1-benzyl-4-(3-(N-t-butyloxycarbonyl-N-methylamino)benzoylamino)-5-imidazole carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Pyridineacetic acid, hydrochloride (1:1) | HCID 2723724 | — |
| 反応物 | 1-benzyl-4-amino-1H-imidazole-5-carboxamide | HCID 14000620 | — |
| 反応物 | 3-(N-Boc-N-methylamino)benzoic acid | HCID 22349165 | — |
| 生成物 | 1-benzyl-4-(3-(N-t-butyloxycarbonyl-N-methylamino)benzoylamino)-5-imidazole carboxamide | HCID 18360495 | 81% |
反応手順
An amidation reaction and post-treatment were carried out under the same conditions as in Example 17, using 0.65 g (3.0 mmol) of 4-amino-1-benzyl-5-imidazolecarboxamide which was prepared in the same manner as in Reference Example 2 and 3-(N-t-butyloxycarbonyl-N-methylamino)benzoic acid, instead of 3-pyridylacetic acid hydrochloride, to obtain 1.09 g of 1-benzyl-4-(3-(N-t-butyloxycarbonyl-N-methylamino)benzoylamino)-5-imidazole carboxamide (yield 81%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06310070B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-e276764799474190a0415b2940ed430a |
| 出典メモ | uspto-grants-2001_10 |