化工社化工社 化学情報印刷レポート · 研究参考用
2-Fluorobenzoyl chloride → 1-(4-t-Butylbenzyl)-4-(2-fluorobenzoylamino)-5-imidazolecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Fluorobenzoyl chloride | HCID 9808 | — |
| 反応物 | 4-Amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide | HCID 18360289 | — |
| 生成物 | 1-(4-t-Butylbenzyl)-4-(2-fluorobenzoylamino)-5-imidazolecarboxamide | HCID 18360610 | 89% |
反応手順
An amidation reaction and post-treatment were carried out under the same conditions as in Example 1, using 1.91 g (7.01 mmol) of 4-amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide which was prepared in the same manner as in Example 57 and 2-fluorobenzoyl chloride instead of benzoyl chloride to obtain 2.47 g of 1-(4-t-butylbenzyl)-4-(2-fluorobenzoylamino)-5-imidazolecarboxamide (yield 89%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06310070B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-4bfd908c429048888f86a59332142c35 |
| 出典メモ | uspto-grants-2001_10 |