Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl- → HCID 18360232、化合物

反応式

[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[C:18]([O:22][C:23]([N:25]([CH2:27][C:28](O)=[O:29])[CH3:26])=[O:24])([CH3:21])([CH3:20])[CH3:19]>>[C:18]([O:22][C:23]([N:25]([CH2:27][C:28]([NH:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8])=[O:29])[CH3:26])=[O:24])([CH3:21])([CH3:20])[CH3:19]

参加物

反応物 2

HCID 83692Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-

HCID 18360275HCID 18360275、化合物

生成物 1

HCID 18360232HCID 18360232、化合物収率 72%

実験手順

An amidation reaction and post-treatment were carried out following the conditions of Example 17, using 2.12 g (9.01 mmol) of 4-amino-1-(4-fluorobenzyl)-5-imidazolecarboxamide prepared in the same manner as in Example 58 and 2-(N-t-butyloxycarbonyl-N-methylamino)acetic acid instead of 3-pyridylacetic acid hydrochloride to obtain 2.63 g of 4-(2-(N-t-butyloxycarbonyl-N-methylamino)acetylamino)-1-(4-fluorobenzyl)-5-imidazolecarboxamide (yield 72%).

後処理

customAn amidation reaction

出典と根拠

ORDレコード: ord-8648b14aaad8437a98111e1958737427
出典データセット: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06310070B1

反応ノート

読み込み中…