化工社化工社 化学情報印刷レポート · 研究参考用
3-Fluorobenzoyl chloride → 1-(4-t-Butylbenzyl)-4-(3-fluorobenzoylamino)-5-imidazolecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Fluorobenzoyl chloride | HCID 74376 | — |
| 反応物 | 4-Amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide | HCID 18360289 | — |
| 生成物 | 1-(4-t-Butylbenzyl)-4-(3-fluorobenzoylamino)-5-imidazolecarboxamide | HCID 18360186 | 70% |
反応手順
An amidation reaction and post-treatment were carried out under the same conditions as in Example 1, using 1.54 g (5.65 mmol) of 4-amino-1-(4-t-butylbenzyl)-5-imidazole carboxamide which was prepared in the same manner as in Example 57 and 3-fluorobenzoyl chloride instead of benzoyl chloride to obtain 1.57 g of 1-(4-t-butylbenzyl)-4-(3-fluorobenzoylamino)-5-imidazolecarboxamide (yield 70%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06310070B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-847f5e17d08143969243a6780ae8fd50 |
| 出典メモ | uspto-grants-2001_10 |