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4-Fluorobenzoyl chloride → 1-(4-t-Butylbenzyl)-4-(4-fluorobenzoylamino)-5-imidazolecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluorobenzoyl chloride | HCID 67879 | — |
| 反応物 | 4-Amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide | HCID 18360289 | — |
| 生成物 | 1-(4-t-Butylbenzyl)-4-(4-fluorobenzoylamino)-5-imidazolecarboxamide | HCID 18360364 | 56% |
反応手順
An amidation reaction and post-treatment were carried out under the same conditions as in Example 1, using 2.63 g (9.66 mmol) of 4-amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide which was prepared in the same manner as in Example 57 and 4-fluorobenzoyl Chloride instead of benzoyl chloride to obtain 2.13 g of 1-(4-t-butylbenzyl)-4-(4-fluorobenzoylamino)-5-imidazolecarboxamide (yield 56%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06310070B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-f381f676ce77489f895b5e0d57d77d03 |
| 出典メモ | uspto-grants-2001_10 |