2-Fluorobenzoyl chloride → HCID 18360552、化合物
反応式
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[F:19][C:20]1[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=1[C:22](Cl)=[O:23]>>[F:19][C:20]1[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=1[C:22]([NH:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:6]=1[C:7]([NH2:9])=[O:8])=[O:23]参加物
3
実験手順
An amidation reaction and post-treatment were carried out following the conditions of Example 22 using 1.50 g (6.14 mmol) of 4-amino-1-(3-phenylpropyl)-5-imidazolecarboxamide which was prepared in the same manner as in Example 114 and 2-fluorobenzoyl chloride instead of benzoyl chloride to obtain 1.97 g of 4-(2-fluorobenzoylamino)-1-(3-phenylpropyl)-5-imidazolecarboxamide (yield 88%).
後処理
- customAn amidation reaction
出典と根拠
- ORDレコード
- ord-f8870f63df584c599d3bdc20ce286c7e
- 出典データセット
- uspto-grants-2001_10