Azido(trimethyl)stannane → Hypoxanthine

HRID 382432ノート

反応式

HRID 382432 の反応式
C(C1C=CC=CC=1C1C=CC(C[N:14]2[C:18]([C:19]([NH2:21])=[O:20])=[C:17]([NH:22][C:23](=O)CC)[N:16]=[CH:15]2)=CC=1)#N.C[Sn](N=[N+]=[N-])(C)C>C1(C)C=CC=CC=1>[NH:21]1[C:19](=[O:20])[C:18]2[NH:14][CH:15]=[N:16][C:17]=2[N:22]=[CH:23]1

参加物

4

反応物 2

HCID 5104973Azido(trimethyl)stannaneHCID 183601781-(4-(2-Cyanophenyl)benzyl)-4-propanoylamino-5-imidazole carboxamide

生成物 1

HCID 135398638Hypoxanthine収率 83%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

2.17 g (5.81 mmol) of the amide thus prepared was suspended in 30 ml of toluene and 5.00 g (24.3 mmol) of trimethyl tin azide was added to the suspension, followed by heating for 23 hours while refluxing. Crystals produced was separated by filtration and dissolved in methanol containing 1N hydrochloric acid. The solution was neutralized with 4 N sodium hydroxide aqueous solution. After evaporating methanol, crystals collected by filtration was purified by suspending them in hot methanol, thereby obtaining 1.93 g of 2-ethyl-7-(4-2-tetrazolylphenyl)benzyl)hypoxanthine (yield 83%).

後処理

  1. temperatureby heating for 23 hours
  2. temperaturewhile refluxing
  3. customCrystals produced
  4. customwas separated by filtration
  5. dissolutiondissolved in methanol containing 1N hydrochloric acid
  6. customAfter evaporating methanol, crystals
  7. filtrationcollected by filtration
  8. customwas purified

出典と根拠

ORDレコード
ord-2bc02e0a4b2e4d52a01374bbb12c7810
出典データセット
uspto-grants-2001_10
特許番号
US06310070B1

反応ノート

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