Oxalic Acid → (E)-1-(2-Pyrimidyl)-2-styryl-1H-benzimidazole oxalate

HRID 382520

反応式

HRID 382520 の反応式
[CH:1]([C:9]1[NH:13][C:12]2[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=2[N:10]=1)=[CH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl[C:19]1[N:24]=[CH:23][CH:22]=[CH:21][N:20]=1.N1C=CC=CC=1N1C2C=CC=CC=2N=C1/C=C/C1C=CC=CC=1.[C:48]([OH:53])(=[O:52])[C:49]([OH:51])=[O:50]>C(OCC)(=O)C>[C:48]([OH:53])(=[O:52])[C:49]([OH:51])=[O:50].[N:20]1[CH:21]=[CH:22][CH:23]=[N:24][C:19]=1[N:13]1[C:12]2[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=2[N:10]=[C:9]1/[CH:1]=[CH:2]/[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

6

反応物 4

HCID 971Oxalic AcidHCID 744042-ChloropyrimidineHCID 2429652-(2-Phenylethenyl)-1h-benzimidazoleHCID 9796241(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole

生成物 1

HCID 9930183(E)-1-(2-Pyrimidyl)-2-styryl-1H-benzimidazole oxalate

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 2-chloropyrimidine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base and oxalic acid were dissolved into ethyl acetate. Concentration and recrystallization from ethyl acetate/n-hexane yielded the titled compound.

後処理

  1. concentrationConcentration and recrystallization from ethyl acetate/n-hexane

出典と根拠

ORDレコード
ord-d0e501acd8bd441a9a50c84f5696825d
出典データセット
uspto-grants-2001_10
特許番号
US06310079B1

関連ノート

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