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Oxalic Acid → (E)-3,4-Dimethoxystyryl-1-(2-pyridyl)-1H-benzimidazole oxalate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Oxalic Acid | HCID 971 | — |
| 反応物 | N1-(pyridin-2-yl)benzene-1,2-diamine | HCID 752150 | — |
| 反応物 | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| 反応物 | 3,4-Dimethoxycinnamoylchloride | HCID 53399206 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | (E)-3,4-Dimethoxystyryl-1-(2-pyridyl)-1H-benzimidazole oxalate | HCID 69914538 | — |
反応手順
Free base of the titled compound was prepared from N-(2-pyridyl)-o-phenylenediamine and 3,4-dimethoxycinnamoyl chloride (Ramamurthy, B.; Sugumaran, M. Synthesis, 1987, 523) according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base and oxalic acid were dissolved into ethyl acetate. Concentration and recrystallization from ethyl acetate/n-hexane yielded the titled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06310079B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-703a92826bf54efe8e7f23d7dcd68d88 |
| 出典メモ | uspto-grants-2001_10 |