化工社化工社 化学情報印刷レポート · 研究参考用
3,4-dihydro-2H-pyran → 2H-Pyran, tetrahydro-2-[4-(trifluoromethyl)phenoxy]-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| 反応物 | 4-(Trifluoromethyl)phenol | HCID 67874 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2H-Pyran, tetrahydro-2-[4-(trifluoromethyl)phenoxy]- | HCID 11357015 | 133.3% |
反応手順
A solution of 4-(Trifluoromethyl)-phenol (40 g) in dichloromethane (100 ml) was added at 0° C. dropwise to a solution of dihydropyran (53 g) in dichloromethane (100 ml) and aqueous HCl (200 μl) The reaction was allowed to reach room temperature, then quenched with saturated sodium bicarbonate (×1). The organic layer was separated and dried (MgSO4), concentrated in vacuo to give the sub-title compound (81 g)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524715B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-974d465cc163410786a446a46acbbc0e |
| 出典メモ | uspto-grants-2013_09 |