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Hydrochloric Acid → (E)-5-Methyl-2-(4-methoxystyryl)-1-(2-pyridyl)-1H-benzimidazole hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-Methyl-2-nitroaniline | HCID 6978 | — |
| 反応物 | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| 反応物 | trans-4-Methoxycinnamoyl chloride | HCID 10976422 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (E)-5-Methyl-2-(4-methoxystyryl)-1-(2-pyridyl)-1H-benzimidazole hydrochloride | HCID 18360812 | — |
反応手順
Free base of the titled compound was prepared from 4-methyl-2-nitroaniline and (E)-4-methoxycinnamoyl chloride according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base was dissolved with a 10% methanol solution of hydrogen chloride (5 ml). Concentration and recrystallization from ethyl acetate/ethanol yielded the titled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06310079B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-1b3ce5fe73c64cc1b630a5b48c7e592d |
| 出典メモ | uspto-grants-2001_10 |