Diethyl Ether → (2-acetyl-4-chlorophenoxy)-acetic Acid, 1,1-dimethylethyl Ester

HRID 38259

反応式

HRID 38259 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1.C(=O)([O-])[O-].[K+].[K+].[C:18]([O:22][C:23](=[O:26])[CH2:24]Br)([CH3:21])([CH3:20])[CH3:19].C(OCC)C>CN(C=O)C.O>[C:8]([C:6]1[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=1[O:11][CH2:24][C:23]([O:22][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:26])(=[O:10])[CH3:9]

参加物

7

反応物 4

HCID 3283Diethyl EtherHCID 11430Potassium CarbonateHCID 740613-Chloro-6-hydroxyacetophenoneHCID 79177tert-Butyl bromoacetate

生成物 1

HCID 67131695(2-acetyl-4-chlorophenoxy)-acetic Acid, 1,1-dimethylethyl Ester

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 1-(5-chloro-2-hydroxyphenyl)-ethanone (2 g), potassium carbonate (1.62 g) and tert-butylbromoacetate (1.73 ml) in DMF (5 ml) was stirred at ambient temperature for 16 h. Diethyl ether and water were added and the organic layer separated, it was washed with water, aqueous potassium carbonate solution, brine, dried (Na2SO4) and the solvent removed in vacuo to give the sub-title compound (2.84 g).

後処理

  1. customthe organic layer separated
  2. washit was washed with water, aqueous potassium carbonate solution, brine
  3. dry with materialdried (Na2SO4)
  4. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-e58e506d526849c4b183a9ac5b1d2265
出典データセット
uspto-grants-2013_09
特許番号
US08524715B2

関連ノート

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