関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Phenylmethanesulfonyl chloride | HCID 74740 | — |
| 反応物 | tert-butyl N-(pyrrolidin-3-yl)carbamate | HCID 2757234 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | [1-[(Phenylmethyl)sulfonyl]-3-pyrrolidinyl]-carbamic acid, 1,1-dimethylethyl ester | HCID 91332323 | 65.9% |
反応手順
To a solution/suspension of 3-pyrrolidinyl-carbamic acid, 1,1-dimethylethyl ester (0.5 g) and triethylamine (0.38 ml) in dichloromethane (30 ml) at 0° C. was added benzenemethanesulfonyl chloride (0.51 g). The mixture was stirred at 0° C. for 30 minutes then stirred at room temperature for 2 days. The reaction was diluted with dichloromethane (20 ml) washed with water, saturated aq. NaHCO3(aq), dried (MgSO4) and concentrated in vacuo to give the sub-title compound (0.6 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08524715B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-dbe3b2d374234cb39ea5c3d57766ebce |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
