化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → 4-(1-Methyl-2-oxo-2-phenylethyl)-1-piperazinecarboxylic acid, 1,1-dimethylethyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 2-Phenylpropionic acid | HCID 10296 | — |
| 反応物 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4-(1-Methyl-2-oxo-2-phenylethyl)-1-piperazinecarboxylic acid, 1,1-dimethylethyl Ester | HCID 86631060 | — |
反応手順
To N-BOC-piperazine (0.373 g) in DMF (10 ml) was added HATU (1.14 g) followed by 2-phenylpropionic acid (0.30 ml) and the reaction stirred at RT for 16 h followed by 60° C. for 1 h. The reaction was cooled to RT, then diluted with diethyl ether, washed with water (×3), 2M HCl (×2), saturated aq. NaHCO3 (aq) (×2), dried (Na2SO4) and concentrated in vacuo to give the sub-titled compound (0.25 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524715B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-16acc7c4cde945e59cce37a822ebe269 |
| 出典メモ | uspto-grants-2013_09 |