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4-Benzylpiperidine → 4[-2-(4-Benzyl-piperidine-1-yl)-ethanesulfonyl]-phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Benzylpiperidine | HCID 31738 | — |
| 反応物 | 4-(2-Chloro-ethanesulfonyl)-phenol | HCID 9813249 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4[-2-(4-Benzyl-piperidine-1-yl)-ethanesulfonyl]-phenol | HCID 9798945 | 38.7% |
反応手順
To a solution of 40.0 g 4-(2-chloro-ethanesulfonyl)-phenol (181 mmol) in 600 ml CH2Cl2 were added 69.9 g 4-benzylpiperidine (399 mmol). After stirring for 16 h at r. t. the reaction mixture was concentrated to 100 ml and directly purified by chromatography over silica gel (CH2Cl2/MeOH/NH3 19/1/0.1). Recrystallization from ethyl acetatelhexane (2:1) yielded 25 g product (70 mmol, 38%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06310213B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-840af965b37549a1b786c559c48d75aa |
| 出典メモ | uspto-grants-2001_10 |