Benzyl Bromide → cis-2-benzyl-8-fluoro-1,3,4,4a,5,10b-hexahydro-2H-benzo[h]isoquinolin-6-one
反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[C@H:14]3[C@H:9]([CH2:10][CH2:11][NH:12][CH2:13]3)[CH2:8][C:7](=[O:15])[C:6]=2[CH:16]=1.[CH2:17](Br)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:17]([N:12]1[CH2:11][CH2:10][C@H:9]2[C@H:14]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:16][C:6]=3[C:7](=[O:15])[CH2:8]2)[CH2:13]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1参加物
3
実験手順
In an analogous manner to that described in Example 49 b), from cis-8-fluoro-1,3,4,4a,5,10b-hexahydro-2H-benzo[h]isoquinolin-6-one by alkylation with benzyl bromide there was obtained cis-2-benzyl-8-fluoro-1,3,4,4a,5,10b-hexahydro-2H-benzo[h]isoquinolin-6-one, which was converted with MeOH/HCl into the hydrochloride with m.p. >220°.
出典と根拠
- ORDレコード
- ord-38164eb1d710406fbb663af5d452fd9a
- 出典データセット
- uspto-grants-2001_10
- 特許番号
- US06310208B1
反応ノート
読み込み中…