Hydrochloric Acid → Ethyl dodecanoyl-3, 5-dimethylpyrrole-2-carboxylate

HRID 382821ノート

反応式

HRID 382821 の反応式
[Al+3].[Cl-].[Cl-].[Cl-].[CH3:5][C:6]1[CH:10]=[C:9]([CH3:11])[NH:8][C:7]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13].[C:17](Cl)(=[O:29])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28].Cl>O.ClCCl>[C:17]([C:10]1[C:6]([CH3:5])=[C:7]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[NH:8][C:9]=1[CH3:11])(=[O:29])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 8166Dodecanoyl chlorideHCID 1374771H-Pyrrole-2-carboxylic acid, 3,5-dimethyl-, ethyl esterHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 18362055Ethyl dodecanoyl-3, 5-dimethylpyrrole-2-carboxylate

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

1.46 g (11 mmol) of AlCl3 were added to a solution of 1.67 g (10 mmol) of ethyl 3,5-dimethylpyrrole-2-carboxylate a 2.63 g (12 mmol) of dodecanoyl chloride in 30 ml of absol. Dichloromethane and then stirred for 24 h. Addition of water and dilute HCl is followed by extraction twice with CH2Cl2. The organic phases are washed with dilute NaOH, dried over Na2SO4 and concentrated. The product is recrystallized from isopropanol.

後処理

  1. extractionis followed by extraction twice with CH2Cl2
  2. washThe organic phases are washed with dilute NaOH
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated
  5. customThe product is recrystallized from isopropanol

出典と根拠

ORDレコード
ord-85823facb44a4b2297b82673efd223d8
出典データセット
uspto-grants-2001_10
特許番号
US06310217B1

反応ノート

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