化工社化工社 化学情報印刷レポート · 研究参考用
1-Bromo-3-chloropropane → 1-(4-Fluorobenzyl)-4-(3-chloropropyl) piperazine dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Bromo-3-chloropropane | HCID 8006 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 1-(4-Fluorobenzyl)piperazine | HCID 796563 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 1-(4-Fluorobenzyl)-4-(3-chloropropyl) piperazine dihydrochloride | HCID 20153168 | 179.2% |
反応手順
The procedure described in Example 1(a) was followed, using 32.8 g of 1-(4-fluorobenzyl)piperazine, 30.0 g of potassium hydroxide, 100 ml of dimethyl sulfoxide and 27.0 g of 1-bromo-3-chloropropane. Work-up, as described above, gave 35.2 g (61% of theory) of 1-(4-fluorobenzyl)-4-(3-chloropropyl) piperazine dihydrochloride as a white crystalline solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04722926 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-734f4d7e69b04aab8269e26db78ea339 |
| 出典メモ | uspto-grants-1988_02 |