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2-Acetoxypropionyl Chloride → 5-(2-Acetoxypropionylamino)-3-acetoxymethyl-N-(2,3-diacetoxypropyl)-2,4,6-triiodobenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Acetoxypropionyl Chloride | HCID 4547492 | — |
| 反応物 | 3-Acetoxymethyl-5-(2,3-diacetoxypropylaminocarbonyl)-2,4,6-triiodoaniline | HCID 18429130 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | 5-(2-Acetoxypropionylamino)-3-acetoxymethyl-N-(2,3-diacetoxypropyl)-2,4,6-triiodobenzamide | HCID 18429188 | 100% |
反応手順
5-Amino-3-acetoxymethyl-N-(2,3-diacetoxypropyl)-2,4,6-triiodobenzamide (3.20 g, 4.3 mmol) was dissolved in dry dimethylacetamide (4 ml). 2-Acetoxypropionyl chloride (2.17 ml, 17.2 mmol) was then added dropwise with efficient stirring. Stirring was continued over night. After work up according to the procedure in Example 24i, 3.66 g (100%) of product was isolated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06310243B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-1d2e02de960d42468d097c0e4628acfe |
| 出典メモ | uspto-grants-2001_10 |