Bromine → Ethyl 3-bromo-4-oxobutanoate

HRID 383111

反応式

HRID 383111 の反応式
[CH2:1]([O:3][C:4](=[O:9])[CH2:5][CH2:6][CH:7]=[O:8])[CH3:2].[Br:10]Br>C(OCC)C>[CH2:1]([O:3][C:4](=[O:9])[CH2:5][CH:6]([Br:10])[CH:7]=[O:8])[CH3:2]

参加物

4

反応物 2

HCID 24408BromineHCID 82395Ethyl 4-oxobutanoate

生成物 1

HCID 15576269Ethyl 3-bromo-4-oxobutanoate収率 66.5%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a 0-5° C. mechanically-stirred solution in diethyl ether (100 mL) of succinaldehydic acid ethyl ester (10.0 g, 77 mmol) was added bromine (3.9 g, 151 mmol) over 2.5 hours. The reaction mixture was stirred for an additional 1.25 hours and the ether was distilled at atmospheric pressure. The remaining yellow oil was distilled (6.0-6.5 mm Hg, bp 95-101° C.) to give 3-bromosuccinaldehydic acid ethyl ester (10.7 g, 66%).

後処理

  1. distillationthe ether was distilled at atmospheric pressure
  2. distillationThe remaining yellow oil was distilled (6.0-6.5 mm Hg, bp 95-101° C.)

出典と根拠

ORDレコード
ord-e27d267f52fb48c582371c116a9045d5
出典データセット
uspto-grants-2001_10
特許番号
US06310095B1

関連ノート

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