Hydrochloric Acid → HCID 54048152、化合物
反応式
Cl.[C:2]1([CH2:8][C@H:9]([NH2:13])[CH2:10][O:11][CH3:12])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>C(O)C.[Pt]=O>[CH:2]1([CH2:8][C@H:9]([NH2:13])[CH2:10][O:11][CH3:12])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1参加物
5
実験手順
To a solution of (S)-3-phenyl-1-methoxy-2-propylamine hydrochloride (0.5 g) in ethanol (100 ml) was added concentrated HCl (0.32 mL), and platinum oxide (0.5 g), and the reaction was shaken under hydrogen gas (4 atm) for 18 h. The reaction was filtered, concentrated, diluted with water (50 mL) and neutralized with IM NaOH (to pH≈11). The mixture was washed with chloroform (3×50 mL), and the organic extracts were washed with brine (20 mL), dried (M.SO4), filtered and concentrated to give a colorless oil (400 mg).
後処理
- filtrationThe reaction was filtered
- concentrationconcentrated
- additiondiluted with water (50 mL)
- washThe mixture was washed with chloroform (3×50 mL)
- washthe organic extracts were washed with brine (20 mL)
- customdried (M.SO4)
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-0f25ad94556d4f678e05d4c338eba960
- 出典データセット
- uspto-grants-2001_10
- 特許番号
- US06310095B1
反応ノート
読み込み中…