5-Bromo-2-ethylpyrimidine-4-carboxylic acid → 5-Bromo-2-ethylpyrimidine

HRID 383258

反応式

HRID 383258 の反応式
[Br:1][C:2]1[C:3](C(O)=O)=[N:4][C:5]([CH2:8][CH3:9])=[N:6][CH:7]=1>C1(C)C(C)=CC=CC=1>[Br:1][C:2]1[CH:3]=[N:4][C:5]([CH2:8][CH3:9])=[N:6][CH:7]=1

参加物

3

反応物 1

HCID 669777025-Bromo-2-ethylpyrimidine-4-carboxylic acid

生成物 1

HCID 251500695-Bromo-2-ethylpyrimidine収率 38%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

A mixture of 5-Bromo-2-ethylpyrimidine-4-carboxylic acid (5.6 g, 24.3 mmol) in xylene (50 mL) was refluxed for 2 h. After cooling, the mixture was applied directly to a silica column, which was eluted with petroleum ether, then ethyl acetate in petroleum ether (5%) to give compound 0601-121 (1.7 g, 38%) as a yellow liquid. 1H NMR (400 MHz, DMSO-d6): 1.26 (t, J=7.6 Hz, 3H), 2.87 (q, J=7.6 Hz, 2H), 8.90 (s, 2H).

後処理

  1. temperaturewas refluxed for 2 h
  2. temperatureAfter cooling
  3. washwas eluted with petroleum ether

出典と根拠

ORDレコード
ord-545b3de311dc4edeb15dc990a64ffdcc
出典データセット
uspto-grants-2013_02
特許番号
US08367663B2

関連ノート

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