Bromine → 3-Bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine

HRID 383313ノート

反応式

HRID 383313 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[CH:5][C:6]2[N:7]([CH:9]=[CH:10][N:11]=2)[CH:8]=1.[Br:14]Br>C(O)(=O)C>[Br:14][C:9]1[N:7]2[CH:8]=[C:3]([C:2]([F:1])([F:12])[F:13])[CH:4]=[CH:5][C:6]2=[N:11][CH:10]=1

参加物

4

反応物 2

HCID 24408BromineHCID 401480116-(Trifluoromethyl)imidazo[1,2-a]pyridine

生成物 1

HCID 455882283-Bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To 6-trifluoromethyl-imidazo[1,2-a]pyridine (1 eq, 6.2 mmol, 1.1 g) in acetic acid (15 ml) under an inert atmosphere of argon is added dropwise bromine (1 eq, 6.2 mmol, 0.313 ml). After stirring at room temperature for 1 hour, the reaction mixture is filtered to afford the title compound as a beige solid; [M+H]+=266(268)

後処理

  1. filtrationthe reaction mixture is filtered

出典と根拠

ORDレコード
ord-0ac4adbf422b4f86acf1b097b950f24c
出典データセット
uspto-grants-2013_02
特許番号
US08367662B2

反応ノート

読み込み中…