Ethyl{3-[3-(4-cyanophenyl)-6-oxo-6h-pyridazin-1-ylmethyl]phenyl}carbamate → Ethyl{3-[3-(4-aminomethylphenyl)-6-oxo-6h-pyridazin-1-ylmethyl]phenyl}carbamate

HRID 383636ノート

反応式

HRID 383636 の反応式
[CH2:1]([O:3][C:4](=[O:28])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][N:13]2[C:18](=[O:19])[CH:17]=[CH:16][C:15]([C:20]3[CH:25]=[CH:24][C:23]([C:26]#[N:27])=[CH:22][CH:21]=3)=[N:14]2)[CH:7]=1)[CH3:2]>N.[Ni]>[CH2:1]([O:3][C:4](=[O:28])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][N:13]2[C:18](=[O:19])[CH:17]=[CH:16][C:15]([C:20]3[CH:21]=[CH:22][C:23]([CH2:26][NH2:27])=[CH:24][CH:25]=3)=[N:14]2)[CH:7]=1)[CH3:2]

参加物

4

反応物 1

HCID 59406745Ethyl{3-[3-(4-cyanophenyl)-6-oxo-6h-pyridazin-1-ylmethyl]phenyl}carbamate

生成物 1

HCID 59406699Ethyl{3-[3-(4-aminomethylphenyl)-6-oxo-6h-pyridazin-1-ylmethyl]phenyl}carbamate

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 222Ammonia溶媒

実験手順

26 mmol of ethyl{3-[6-oxo-3-(4-cyanophenyl)-6H-pyridazin-1-ylmethyl]-phenyl}carbamate are dissolved in 300 ml of methanolic ammonia solution (10%), 4 g of Raney Ni are added, and the mixture is hydrogenated at room temperature for 16 h under a hydrogen atmosphere (5 bar). The catalyst is separated off, rinsed with methanol, and the filtrate is evaporated.

後処理

  1. customThe catalyst is separated off
  2. washrinsed with methanol
  3. customthe filtrate is evaporated

出典と根拠

ORDレコード
ord-462b1582d16c4c04a98219049b4e765f
出典データセット
uspto-grants-2013_02
特許番号
US08367668B2

反応ノート

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