3-(Propan-2-yloxy)aniline → 5-(3-Isopropoxyphenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde

HRID 383680ノート

反応式

HRID 383680 の反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[CH:9][C:10]([CH:11]=[O:12])=[C:4]2[N:3]=1.[CH:13]([O:16][C:17]1[CH:18]=[C:19]([CH:21]=[CH:22][CH:23]=1)[NH2:20])([CH3:15])[CH3:14]>O1CCOCC1>[CH:13]([O:16][C:17]1[CH:18]=[C:19]([NH:20][C:2]2[CH:7]=[CH:6][N:5]3[N:8]=[CH:9][C:10]([CH:11]=[O:12])=[C:4]3[N:3]=2)[CH:21]=[CH:22][CH:23]=1)([CH3:15])[CH3:14]

参加物

4

反応物 2

HCID 5732203-(Propan-2-yloxy)anilineHCID 581964015-Chloropyrazolo(1,5-a)pyrimidine-3-carbaldehyde

生成物 1

HCID 581966625-(3-Isopropoxyphenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
120 °C

実験手順

To 5-chloropyrazolo[1,5-a]pyrimidine-3-carbaldehyde (50 mg, 0.276 mmol) in dioxane was added 3-isopropoxyaniline (125 mg, 0.829 mmol). The mixture was heated in microwave for 20 minutes at 120° C. The solid produced was isolated by filtration and then purified by preparative TLC (2% MeOH/DCM) to yield 5-(3-isopropoxyphenylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde. LCMS (M+1=297)

後処理

  1. customThe solid produced
  2. customwas isolated by filtration
  3. custompurified by preparative TLC (2% MeOH/DCM)

出典と根拠

ORDレコード
ord-0943c62de7e54027beef998dc3b3cde0
出典データセット
uspto-grants-2013_02
特許番号
US08367681B2

反応ノート

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