Hydrazine → tert-Butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate

HRID 383769ノート

反応式

HRID 383769 の反応式
C[C:2]1([C:14]([O-:16])=O)[CH2:6][CH2:5][N:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:3]1.[NH2:17][NH2:18]>C(O)C>[NH:17]([C:14]([CH:2]1[CH2:6][CH2:5][N:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:3]1)=[O:16])[NH2:18]

参加物

4

反応物 2

HCID 9321HydrazineHCID 713021051-Tert-butyl 3-methylpyrrolidine-1,3-dicarboxylate

生成物 1

HCID 4621605tert-Butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 1-tert-butyl 3-methylpyrrolidine-1,3-dicarboxylate (1.00 equiv.) and hydrazine (excess of 50% aq. solution) in ethanol (0.2 M final conc.) is heated to reflux. After the reaction is deemed complete, the reaction mixture is cooled to rt and partially concentrated. The resulting mixture is diluted with EtOAc, and the resulting organics are washed with water and brine, dried (sodium sulfate) and concentrated in vacuo to afford the title compound i-13a.

後処理

  1. concentrationpartially concentrated
  2. additionThe resulting mixture is diluted with EtOAc
  3. washthe resulting organics are washed with water and brine
  4. dry with materialdried (sodium sulfate)
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-e8ae6410e69b4506a1f42e3668b7c4fb
出典データセット
uspto-grants-2013_02
特許番号
US08367679B2

反応ノート

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