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HRID 383827作成日：2026年10月27日
Acetic Acid → 7-(4-(2-(4-Cyanopyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide
https://huagongshe.com/reaction/383827
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 2-Vinylisonicotinonitrile | HCID 45080048 | — |
| 反応物 | N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide | HCID 59636743 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 7-(4-(2-(4-Cyanopyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide | HCID 66847540 | — |
反応手順
The compound was prepared according to the procedure disclosed in Example 39 starting from of 2-vinylisonicotinonitrile (0.076 g, 0.59 mmol), N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide (0.080 g, 0.29 mmol) (Example 39d), and acetic acid (0.013 mL, 0.23 mmol). Ethanol was used as solvent and the reaction heated at 90° C. for two days. The crude product was purified by preparative HPLC to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08367676B2 |
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| 出典データセット | uspto-grants-2013_02 |
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| ORD ID | ord-51688835e6bf46c0b7feffc884d64030 |
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| 出典メモ | uspto-grants-2013_02 |
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