Acetic Acid → Azetidin-1-yl(7-(piperazin-1-yl)benzofuran-2-yl)methanone

HRID 383834

反応式

HRID 383834 の反応式
[N:1]1([C:5]([C:7]2[O:8][C:9]3[C:15]([N:16]4[CH2:21][CH2:20][N:19](CC5C=CC=CC=5)[CH2:18][CH2:17]4)=[CH:14][CH:13]=[CH:12][C:10]=3[CH:11]=2)=[O:6])[CH2:4][CH2:3][CH2:2]1.C(O)(=O)C.N>>[N:1]1([C:5]([C:7]2[O:8][C:9]3[C:15]([N:16]4[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]4)=[CH:14][CH:13]=[CH:12][C:10]=3[CH:11]=2)=[O:6])[CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 3

HCID 176Acetic AcidHCID 222AmmoniaHCID 59636710Azetidin-1-yl(7-(4-benzylpiperazin-1-yl)benzofuran-2-yl)methanone

生成物 1

HCID 59636763Azetidin-1-yl(7-(piperazin-1-yl)benzofuran-2-yl)methanone

実験手順

The compound was prepared according to the procedure disclosed in Example 39d starting from azetidin-1-yl(7-(4-benzylpiperazin-1-yl)benzofuran-2-yl)methanone (0.52 g, 1.38 mmol) and acetic acid (0.63 mL, 11.1 mmol). A solution of ammonia (3 mL, 7N in MeOH) was added to the mixture after the reaction was complete. The solvent was removed by rotary evaporation. The crude product was purified by flash chromatography (SiO2; gradient 0-10% ammonia (7N in MeOH) in DCM). Yield: 0.36 g (91%).

後処理

  1. customThe compound was prepared
  2. customThe solvent was removed by rotary evaporation
  3. customThe crude product was purified by flash chromatography (SiO2; gradient 0-10% ammonia (7N in MeOH) in DCM)

出典と根拠

ORDレコード
ord-97d8016b45934f8389c9ddd985f0c489
出典データセット
uspto-grants-2013_02
特許番号
US08367676B2

関連ノート

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