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HRID 383840作成日：2026年10月26日

2-(5-Fluoropyridin-2-yl)ethyl 4-methylbenzenesulfonate → 7-(4-(2-(5-Fluoropyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide

https://huagongshe.com/reaction/383840

反応式

関与物質

役割名称HCID仕込み量
反応物2-(5-Fluoropyridin-2-yl)ethyl 4-methylbenzenesulfonateHCID 59636712—
反応物N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamideHCID 59636743—
生成物7-(4-(2-(5-Fluoropyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamideHCID 59636731—

反応手順

The compound was prepared according to the procedure disclosed in Example 46 starting from N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide (0.085 g, 0.31 mmol) (Example 39d) and 2-(5-fluoropyridin-2-yl)ethyl 4-methylbenzenesulfonate (0.092 g, 0.31 mmol). The product was purified by preparative HPLC to give the title compound. Yield: 0.049 g (39%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08367676B2
出典データセットuspto-grants-2013_02
ORD IDord-cb8e84e2a98748689f182a4ec8719589
出典メモuspto-grants-2013_02