Hydrochloric Acid → 1-Azabicyclo[2.2.1]heptan-3-ol hydrochloride

HRID 383945ノート

反応式

HRID 383945 の反応式
[N:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[C:3](=[O:8])[CH2:2]2.[ClH:9]>[Pt]=O.CCO>[ClH:9].[N:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([OH:8])[CH2:2]2

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 108554071-Azabicyclo[2.2.1]heptan-3-one

生成物 1

HCID 685941551-Azabicyclo[2.2.1]heptan-3-ol hydrochloride

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

A mixture of 1-azabicyclo[2.2.1]heptan-3-one (Journal of Medicinal Chemistry, 1990, 33, pp. 2690-2697), hydrochloride (350 mg), platinum oxide (35 mg), and EtOH (5 mL) was stirred at room temperature under a hydrogen atmosphere. The reaction mixture was filtered through Celite, and the filtrate was concentrated under reduced pressure to obtain 1-azabicyclo[2.2.1]heptan-3-ol hydrochloride as a pale brown solid.

後処理

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-91301bffe9f34608abe4a4981fa409e6
出典データセット
uspto-grants-2013_02
特許番号
US08367696B2

反応ノート

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