HCID 86641942、化合物 → HCID 67272423、化合物

HRID 384119ノート

反応式

HRID 384119 の反応式
Cl[C:2]1[N:7]=[C:6]([CH2:8][OH:9])[C:5]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1>C(O)C.[C].[Pd]>[O:10]([C:5]1[C:6]([CH2:8][OH:9])=[N:7][CH:2]=[CH:3][CH:4]=1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

4

反応物 1

HCID 86641942HCID 86641942、化合物

生成物 1

HCID 67272423HCID 67272423、化合物

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

To a solution of (6-chloro-3-phenoxypyridin-2-yl)methanol (88 mg) in ethanol (1.5 ml), 10 mg of 10% palladium-carbon catalyst was added, and the reaction solution was stirred for 20 hours under hydrogen atmosphere. The catalyst was filtered off through Celite, and the filtrate was distilled off under reduced pressure to afford the title compound as a yellow solid.

後処理

  1. filtrationThe catalyst was filtered off through Celite
  2. distillationthe filtrate was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-bd62ea0b8b5c446fa104de0383a94650
出典データセット
uspto-grants-2013_02
特許番号
US08367708B2

反応ノート

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