Potassium Carbonate → 7-Methoxy-2H-1,4-benzoxazin-3(4H)-one
反応式
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][C:7]=1[OH:14])=[O:4].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:13][O:12][C:9]1[CH:10]=[CH:11][C:6]2[NH:5][C:3](=[O:4])[CH2:2][O:14][C:7]=2[CH:8]=1参加物
4
実験手順
2-Chloro-N-(2-hydroxy-4-methoxy-phenyl)-acetamide (390.0 g, 0.18 mol) and powdered potassium carbonate (27.6 g, 0.2 mol) were added to 1000 mL acetone, and the reaction mixture was refluxed under nitrogen for eight hours. The reaction mixture was cooled, solids were removed by filtration, and the liquid was concentrated under reduced pressure to give 32.56 g of crude 7-Methoxy-4H-benzo[1,4]oxazin-3-one. (M+H)=180.
後処理
- temperaturethe reaction mixture was refluxed under nitrogen for eight hours
- temperatureThe reaction mixture was cooled
- customsolids were removed by filtration
- concentrationthe liquid was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-9e4b8690ae714cea8a36d70af5f9d9c2
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524725B2
反応ノート
読み込み中…