化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → N-(2-azidoethyl)thiophene-2-sulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Ethylamine, 2-azido- | HCID 55649 | — |
| 反応物 | 2-Thiophenesulfonyl chloride | HCID 85518 | — |
| 反応物 | N-(2-azidoethyl)tetradecanamide | HCID 57914356 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(2-azidoethyl)thiophene-2-sulfonamide | HCID 57914352 | 80% |
反応手順
As in the synthesis of N-(2-azidoethyl)tetradecanamide, thiophene-2-sulfonyl chloride (0.218 g, 1.19 mmol) was reacted with 2-azidoethanamine (0.103 g, 1.19 mmol) and triethylamine (0.241 g, 2.39 mmol) in dichloromethane (5 mL) to give N-(2-azidoethyl)thiophene-2-sulfonamide (0.221 g, 80%). 1H NMR (300 MHz, CDCl3) δ 7.62 (d, 1H), δ 7.59 (d, 1H), 7.08 (t, 1H), 5.52 (s, 1H), 3.41 (t, 2H), 3.17 (q, 2H) ppm; 13C NMR (75 MHz, CDCl3) δ 140.6, 132.7, 132.6, 127.9, 50.9, 42.9 ppm; HRMS (ESI) calcd for C6H8N4O2S2 (M+) 232.0089, found 232.0084.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08367713B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-2d0c5df0b05845d3aa8d08ceb9878a22 |
| 出典メモ | uspto-grants-2013_02 |