反応式
[N:1]([CH2:4][CH2:5][NH:6]C(=O)CCCCCCCCCCCCC)=[N+:2]=[N-:3].[CH3:22][C:23]1[C:28]([CH3:29])=[C:27]([CH3:30])[C:26]([CH3:31])=[C:25]([CH3:32])[C:24]=1[S:33](Cl)(=[O:35])=[O:34].N(CCN)=[N+]=[N-].C(N(CC)CC)C>ClCCl>[N:1]([CH2:4][CH2:5][NH:6][S:33]([C:24]1[C:23]([CH3:22])=[C:28]([CH3:29])[C:27]([CH3:30])=[C:26]([CH3:31])[C:25]=1[CH3:32])(=[O:35])=[O:34])=[N+:2]=[N-:3]参加物
6
実験手順
As in the synthesis of N-(2-azidoethyl)tetradecanamide, 2,3,4,5,6-pentamethylbenzene-1-sulfonyl chloride (0.304 g, 1.23 mmol) was reacted with 2-azidoethanamine (0.106 g, 1.23 mmol) and triethylamine (0.249 g, 2.46 mmol) in dichloromethane (5 mL) to give N-(2-azidoethyl)-2,3,4,5,6-pentamethylbenzenesulfonamide (0.296 g, 81%). 1H NMR (300 MHz, CDCl3) δ 5.12 (t, 1H) δ 3.35 (t, 2H), δ 3.05 (q, 2H), 2.59 (s, 6H), δ 2.28 (s, 3H), 2.24 (s, 6H) ppm; 13C NMR (75 MHz, CDCl3) δ 139.9, 136.1, 135.2, 134.2, 51.1, 42.3, 19.2, 17.9, 17.3 ppm; HRMS (ESI) calcd for C13H20N4O2S (M+) 296.1307, found 296.1304.
出典と根拠
- ORDレコード
- ord-5825f52646f74078892cdbd0161ef904
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08367713B2
関連ノート
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