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Diisopropylethylamine → ethyl 2-chloro-4-((1-methyl-1H-pyrazol-4-yl)methylamino)pyrimidine-5-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Ethyl 2,4-dichloropyrimidine-5-carboxylate | HCID 104020 | — |
| 反応物 | (1-methyl-1H-pyrazol-4-yl)methanamine | HCID 671225 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | ethyl 2-chloro-4-((1-methyl-1H-pyrazol-4-yl)methylamino)pyrimidine-5-carboxylate | HCID 58098673 | — |
反応手順
To a solution of ethyl 2,4-dichloropyrimidine-5-carboxylate (896 mg, 4 mmol) and (1-methyl-1H-pyrazol-4-yl)methanamine (445 mg, 4 mmol) in CH3CN (6 mL) at room temperature, DIEA (0.783 mL, 4.4 mmol) was added. The mixture was stirred at room temperature for 24 h, and was concentrated to give ethyl 2-chloro-4-((1-methyl-1H-pyrazol-4-yl)methylamino)pyrimidine-5-carboxylate as crude oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08367689B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-dccdebbb7ab3451aaf1cbe32fd927991 |
| 出典メモ | uspto-grants-2013_02 |