Bis(2,2,2-trichloroethyl) hydrazine-1,2-dicarboxylate → Bis(2,2,2-trichloroethyl) 1-(2,3-dihydrobenzofuran-5-yl)hydrazine-1,2-dicarboxylate

Bis(2,2,2-trichloroethyl) 1-(2,3-dihydrobenzofuran-5-yl)hydrazine-1,2-dicarboxylate 2,3-Dihydro-benzofuran 7a (0.6 mL, 5.32 mmol), bis(2,2,2-trichloroethyl) hydrazine-1,2-dicarboxylate (1.96 g, 5.15 mmol) and zinc chloride (920 mg, 6.76 mmol) were dissolved in 40 mL of dichloromethane. The reaction was reacted overnight at room temperature and monitored by TLC until the disappearance of the starting materials. Then the mixture was purified by silica gel column chromatography to obtain the title compound bis(2,2,2-trichloroethyl) 1-(2,3-dihydrobenzofuran-5-yl)hydrazine-1,2-dicarboxylate 7b (2.5 g, yield 96.6%) as a white solid.

1. customThe reaction was reacted overnight at room temperature
2. customThen the mixture was purified by silica gel column chromatography

ORDレコード

ord-3a13d733d8684b419f183f2627834bef

出典データセット

uspto-grants-2013_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08367710B2