Hydrochloric Acid → 4-Bromofuran-2-carboxylic acid

A mixture of 4,5-dibromo-furan-2-carboxylic acid 28a (5.5 g, 20.3 mmol) and 18 mL of ammonium hydroxide was added to 63 mL of water followed by addition of zinc powder (1.46 g, 22.33 mmol). Upon completion of the addition, the reaction mixture was stirred at room temperature for 6 hours. The reaction was monitored by TLC until the disappearance of the starting materials. The mixture was adjusted to pH 3 with hydrochloric acid (1 N) to form a copious amount of precipitates. The mixture was filtered and the filter cake was washed with n-hexane (15 mL×4) and dried to obtain the title compound 4-bromo-furan-2-carboxylic acid 28b (3.2 g, yield 83.1%) as a white solid.

1. additionUpon completion of the addition
2. customto form a copious amount
3. customof precipitates
4. filtrationThe mixture was filtered
5. washthe filter cake was washed with n-hexane (15 mL×4)
6. customdried

ORDレコード

ord-20a137623b97415d9692a718abdc3b24

出典データセット

uspto-grants-2013_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08367710B2