Benzoic Acid → Tolterodine Benzoate

HRID 384428

反応式

HRID 384428 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([OH:24])=[C:6]([C@@H:8]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:9][CH2:10][N:11]([CH:15]([CH3:17])[CH3:16])[CH:12]([CH3:14])[CH3:13])[CH:7]=1.[C:25]([OH:33])(=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>CC(C)=O>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([OH:24])=[C:6]([C@@H:8]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:9][CH2:10][N:11]([CH:12]([CH3:14])[CH3:13])[CH:15]([CH3:16])[CH3:17])[CH:7]=1.[C:25]([O-:33])(=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

参加物

4

反応物 2

HCID 243Benzoic AcidHCID 443879Tolterodine

生成物 1

HCID 86649497Tolterodine Benzoate収率 73.1%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒3 回

実験手順

3.25 g of tolterodine dissolved in 50 mL of acetone was mixed at room temperature (25° C.) with 1.22 g of benzoic acid, which was suspended in 50 mL of acetone, and then stirred. In 10 minutes, there started to appear a solid precipitate. 50 mL of acetone was added thereto and the mixture was stirred at room temperature (25° C.) for 1 hour. The resulting solid precipitate temperature (25° C.) for 24 hours and 3.27 g (theoretical yield: 73.1%) of the final product in white solid was obtained.

後処理

  1. stirringthe mixture was stirred at room temperature (25° C.) for 1 hour
  2. waitThe resulting solid precipitate temperature (25° C.) for 24 hours

出典と根拠

ORDレコード
ord-fb200951ef5046f980e931e6537f699a
出典データセット
uspto-grants-2013_02
特許番号
US08367726B2

関連ノート

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