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Triphenylphosphine → 4-[4-(Benzyloxy)butoxy]-6-(trifluoromethyl)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| 反応物 | 4-Benzyloxy-1-butanol | HCID 562212 | — |
| 反応物 | HCID 178516143 | HCID 178516143 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-[4-(Benzyloxy)butoxy]-6-(trifluoromethyl)pyrimidine | HCID 59527261 | 52.1% |
反応手順
To a solution of 4-(benzyloxy)butan-1-ol (3.00 g), 6-(trifluoromethyl)pyrimidin-4-ol (3.00 g), and triphenylphosphine (5.25 g) in THF (30 mL) was added diisopropyl azodicarboxylate (4.05 g), and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated under reduced pressure, and then the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=9/1) to obtain 4-[4-(benzyloxy)butoxy]-6-(trifluoromethyl)pyrimidine (2.83 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08367702B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-456c051eee1c446ea8710e55bc88f3cb |
| 出典メモ | uspto-grants-2013_02 |