Methyl 4-oxoadamantane-1-carboxylate → 4-Oxoadamantane-1-carboxylic acid

HRID 38451

反応式

HRID 38451 の反応式
C[O:2][C:3]([C:5]12[CH2:14][CH:9]3[CH2:10][CH:11]([CH2:13][CH:7]([C:8]3=[O:15])[CH2:6]1)[CH2:12]2)=[O:4]>[Li+].[OH-].CO>[O:15]=[C:8]1[CH:9]2[CH2:14][C:5]3([C:3]([OH:4])=[O:2])[CH2:12][CH:11]([CH2:13][CH:7]1[CH2:6]3)[CH2:10]2

参加物

3

反応物 1

HCID 4078246Methyl 4-oxoadamantane-1-carboxylate

生成物 1

HCID 28425154-Oxoadamantane-1-carboxylic acid収率 91.5%

試薬・触媒・溶媒 1

HCID 23717829Lithium hydroxide methanol溶媒2 回

実験手順

1.64 g of 4-Oxo-adamantane-1-carboxylic acid methyl ester (10) were dissolved in 4 mL of 2M aq. LiOH/MeOH (1:1) and stirred overnight at room temperature. Additional 5 ml of the MeOH/LiOH mixture were added and stirring was continued until conversion was complete. The reaction mixture was acidified and extracted three times with ethyl acetate. The organic layer was dried over sodium sulphate and evaporated to dryness to give 1.4 g of (11) as a solid. Rt=0.87 min (Method 3). Detected mass: 195.2 (M+H+).

後処理

  1. stirringstirring
  2. extractionextracted three times with ethyl acetate
  3. dry with materialThe organic layer was dried over sodium sulphate
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-b7ee97e955b94020b86d383c0be4c984
出典データセット
uspto-grants-2013_09
特許番号
US08524737B2

関連ノート

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