化工社化工社 化学情報印刷レポート · 研究参考用
4-Amino-1-methylpiperidine → N-(5-Bromo-4-(1-methylpiperidin-4-ylamino)pyridin-2-yl)pivalamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Amino-1-methylpiperidine | HCID 2737531 | — |
| 反応物 | N-(5-bromo-4-chloropyridin-2-yl)-2,2-dimethylpropanamide | HCID 59613421 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | N-(5-Bromo-4-(1-methylpiperidin-4-ylamino)pyridin-2-yl)pivalamide | HCID 59613507 | 99% |
反応手順
A solution of N-(5-bromo-4-chloropyridin-2-yl)pivalamide (0.547 g, 1.87 mmol), 1-methylpiperidin-4-amine (0.600 g, 5.25 mmol) in NMP (3.3 mL) was heated under microwave irradiation for 3 hr at 220° C. The crude mixture was purified by flash chromatography on silica, eluting with methanol and dichloromethane (1/9), to give the title compound as a colourless oil (0.684 g, 99%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08367658B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-0c151141f56b411094efe37edd56e3a5 |
| 出典メモ | uspto-grants-2013_02 |