5-Amino-3-chloropyrazine-2-carbonitrile → 5-Amino-3-methoxypyrazine-2-carbonitrile

HRID 384721

反応式

HRID 384721 の反応式
[NH2:1][C:2]1[N:3]=[C:4](Cl)[C:5]([C:8]#[N:9])=[N:6][CH:7]=1.[CH3:11][O-:12].[Na+].CO>CO.O>[NH2:1][C:2]1[N:3]=[C:4]([O:12][CH3:11])[C:5]([C:8]#[N:9])=[N:6][CH:7]=1

参加物

5

反応物 2

HCID 210753925-Amino-3-chloropyrazine-2-carbonitrileHCID 23694274Sodium methanolate methanol

生成物 1

HCID 596133845-Amino-3-methoxypyrazine-2-carbonitrile収率 58%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

5-Amino-3-chloropyrazine-2-carbonitrile (52 mg, 0.34 mmol) was suspended in NaOMe/MeOH (2M, 2 mL). The reaction mixture was heated at 80° C. for 30 min using microwave irradiation. After cooling, the mixture was diluted with MeOH (3 mL) and water (2 mL). The solvents were concentrated and the resulting precipitate was filtered off, washed with water (3 mL) and dried in vacuo to give the title compound as a yellow solid (33 mg, 58%).

後処理

  1. custommicrowave irradiation
  2. temperatureAfter cooling
  3. concentrationThe solvents were concentrated
  4. filtrationthe resulting precipitate was filtered off
  5. washwashed with water (3 mL)
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-3f89ef85d9d14031bdc39093f3e5c7a0
出典データセット
uspto-grants-2013_02
特許番号
US08367658B2

関連ノート

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