Ammonia → 5-Pyrimidinecarboxaldehyde, 4-amino-6-chloro-

温度

60 °C

NH3 (g) was blown through a solution of 4,6-dichloro-pyrimidine-5-carbaldehyde Compound 1a (50 g, 282.5 mmol) in toluene (565 mL, 0.5M) for 3 mins using a 12C glass frit, then the mixture was warmed at 60° C. with stirring for 30 min. NH3 (g) was blown through the reaction mixture a second time for 3 min and the reaction was heated for 30 mins. NH3 (g) was blown through the reaction mixture a third time for 3 min and the reaction was heated for a final 20 mins. The reaction mixture was diluted with H2O (1 L), and extracted with EtOAc (1×750 mL, 3×500 mL). The organic extracts were washed with brine (4×) and dried (Na2SO4), then concentrated to afford 4-amino-6-chloro-pyrimidine-5-carbaldehyde Compound 1b (38.5 g, 87%) as a yellow solid. 1H NMR (300 MHz, DMSO-d6) δ 10.27 (s, 1H), 8.74 (br s, 1H), 8.58 (br s, 1H), 8.42 (s, 1H).

1. customfor 3 min
2. temperaturethe reaction was heated for 30 mins
3. customfor 3 min
4. temperaturethe reaction was heated for a final 20 mins
5. extractionextracted with EtOAc (1×750 mL, 3×500 mL)
6. washThe organic extracts were washed with brine (4×)
7. dry with materialdried (Na2SO4)
8. concentrationconcentrated

ORDレコード

ord-4bedd63239c14ec7bc7dc051ac5b440a

出典データセット

uspto-grants-2013_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08367825B2